Quinolines and derivatives
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Filtered Search Results
Ambeed R tertButyl 3 hydroxymethyl p
(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate, 278788-66-2, 95%
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Ambeed R tertButyl 3 hydroxymethyl p
(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate, 278788-66-2, 95%
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Medchemexpress LLC BSJ-03-204 | 2349356-09-6 | 99.8% | 832.90 | 1 MG
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BSJ-03-204 is a PROTAC connected by ligands for Cereblon and CDK. It is a potent and selective Palbociclib-based CDK4/6 dual degrader (PROTAC), with IC50s of 26.9 nM for CDK4/D1 and 10.4 nM for CDK6/D1. BSJ-03-204 does not induce IKZF1/3 degradation and exhibits anti-cancer activity.
- Potent anti-proliferative effects on MCL cell lines.
- Potently induces a G1 arrest.
- Selectively degrades CDK4/6 in WT cells, not IKZF1/3.
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Apexbio Technology LLC Nicotinamide Riboside Chloride (NIAGEN)(Synonyms: NR Chloride, Niagen, Nicotinamide Riboside Chloride, NR-Cl, Nicotinamide Riboside Cl), 200mg, CAS: 23111-00-4.
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Nicotinamide Riboside Chloride (NIAGEN CAS 23111-00-4) is a small molecule precursor of nicotinamide adenine dinucleotide (NAD ) an essential cofactor implicated in energy metabolism and cellular homeostasis Upon oral administration it effectively elevates intracellular NAD levels subsequently modulating the activity of NAD -dependent sirtuin enzymes particularly SIRT1 and SIRT3 Experimental evidence indicates that Nicotinamide Riboside Chloride enhances oxidative metabolism and mitigates metabolic dysfunction induced by high-fat dietary conditions Additionally studies employing Alzheimer s disease transgenic mouse models suggest that this compound can reduce cognitive decline supporting its use in biomedical research targeting metabolic and neurodegenerative conditions
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Medchemexpress LLC Selumetinib | 606143-52-6 | 99.6% | C17H15BrClF4O3 | 200 MG
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Selumetinib is a selective, non-ATP-competitive oral MEK1/2 inhibitor with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier. This compound causes a time- and dose-dependent reduction in DNA synthesis and cell viability, inducing growth arrest and apoptosis associated with ERK inactivation.
- Selective, non-ATP-competitive oral MEK1/2 inhibitor
- Inhibits ERK1/2 phosphorylation
- Penetrates the blood-brain barrier
- Induces growth arrest and apoptosis
- Shows anti-proliferative effects
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Ambeed 2 4DibromoN 4bromophenyl N 2 4
2,4-Dibromo-N-(4-bromophenyl)-N-(2,4-dibromophenyl)aniline, 73087-81-7, 95%
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Ambeed Palladium II 2 2 2trifluoroac
Palladium(II) 2,2,2-trifluoroacetate, 42196-31-6, 98%
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Ambeed 5Bromopyridin3amine
5-Bromopyridin-3-amine, 13535-01-8, 98%
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Ambeed 4 4 6Dimethoxy1 3 5triazin2yl
4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium tetrafluoroborate, 293311-03-2, 95%
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Chemscene CHEMSCENE
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5000578828 N-PHENYLANTHRACEN-9-AMINE 25G
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Chemscene CHEMSCENE
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5000579897 8-BROMOQUINOLINE 20G
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Medchemexpress LLC Dihydroergotamine mesylate | 6190-39-2 | 99.9% | 100 MG
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Dihydroergotamine mesylate | 6190-39-2 | 99.9% | 100 MG
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Medchemexpress LLC Indisulam | 165668-41-7 | MFCD00945325 | 99.8% | 385.85 | 200 MG
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Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. This sulfonamide agent targets the G1 phase of the cell cycle, causing a blockade in the G1/S transition. It achieves this by inhibiting the activation of both CDK2 and cyclin E. Additionally, it targets splicing by inducing RBM39 degradation via recruitment to DCAF15.
- Carbonic anhydrase inhibitor
- Exhibits anticancer activity
- Sulfonamide agent
- Targets G1 phase of the cell cycle
- Inhibits CDK2 and cyclin E activation
- Induces RBM39 degradation
- Involved in splicing modulation
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Medchemexpress LLC Nilutamide | 63612-50-0 | 99.7% | 317.22 | 200 MG
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Nilutamide is an orally active nonsteroidal androgen receptor antagonist. It has affinity for androgen receptors but not for progestogen, estrogen, or glucocorticoid receptors. It can be used for research on prostate cancer and also exhibits antischistosomal properties. It inhibits hexobarbital hydroxylase, benzphetamine N-demethylase, benzo(a)pyrene hydroxylase, and 7-ethoxycoumarin O-deethylase activities in human liver microsomes.
- Orally active nonsteroidal androgen receptor antagonist
- Used for research on prostate cancer
- Exhibits antischistosomal properties
- Inhibits hexobarbital hydroxylase and other enzyme activities
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Medchemexpress LLC Dihydralazine sulfate | 7327-87-9 | 100 MG
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Dihydralazine sulfate is a potent vasodilator and an effective antihypertensive agent, primarily used for research purposes. Studies have indicated its ability to inhibit hemorrhagic hypotension without negatively impacting cerebral blood flow in various hypertensive animal models.
- Functions as a vasodilator
- Acts as an antihypertensive agent
- Intended for research use only
- Shown to inhibit hemorrhagic hypotension in in vivo studies
- Maintains cerebral blood flow during blood pressure reduction
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